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Communities in RUIdeRA
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Recent Submissions
Item
Preparation of amides mediated by isopropylmagnesium bromide under continuous flow conditions
(2012) J. M. Muñoz, J. Alcázar, A. de la Hoz, A. Díaz-Ortíz, S.-A. Alonso de Diego
A safe, green and functional-group-tolerant flow version of the direct amide bond formation mediated by Grignard reagents (the Bodroux reaction) is described. The procedure can be applied to a wide variety of primary and secondary amines and anilines, as well as to aromatic and aliphatic esters. The flow approach leads to improved yields and selectivities in the reaction, which has a sustainable purification procedure and a simple scale-up. This reaction represents an efficient and green alternative to the use of alkylaluminium and metal-catalyzed procedures.
Item
DFT-Studies on Cobalt Catalyzed Cyclotrimerization Reactions. Mechanism and Origin of Reaction Improvement under Microwave Irradiation
(Wiley-VCH, 2012) A. M. Rodriguez, C. Cebrián, P. Prieto, J. I. García, A. de la Hoz, Á. Díaz-Ortiz
A DFT computational mechanistic study of the [2+2+2] cyclotrimerization of a diyne with benzonitrile, catalyzed by a cobalt complex, has been carried out. Three alternative catalytic cycles have been examined together with the precatalytic step (responsible for the induction period). The favored mechanism takes place by means of an intramolecular metal-assisted [4+2] cycloaddition. The beneficial role of microwave activation has been studied. It is concluded that microwave irradiation can decrease the catalytic induction period through thermal effects and can also increase the triplet lifetime and promote the reaction, thus improving the final yield.
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Continuous-flow microliter microwave irradiation in the synthesis of isoxazole derivatives. An optimization procedure
(Thieme, 2012) A.M. Rodriguez, A. Juan, M. V. Gómez, A. Moreno, A. de la Hoz
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Sustainable and efficient methodology for CLA synthesis and identification
(RSC, 2012) M. Moreno, M.V. Gomez, C. Cebrian, P. Prieto, A. de la Hoz, A. Moreno
Microwave-assisted organic synthesis and continuous-flow techniques have been successfully employed for the preparation of conjugated linoleic acids (CLA), compounds with high health beneficial effects. A good production rate of CLAwas obtained. A sustainable methodology for the differentiation of both positional and geometrical CLA isomers (diene), based on the analysis by NMR spectroscopy of the resulting Diels–Alder cycloadducts with an appropriate dienophile, was developed.
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Cross- Coupling in flow using supported catalysts: Mild and clean Suzuki-Miyaura coupling in a single pass
(Wiley, 2012) J.M. Muñoz, J. Alcázar, A. de la Hoz, A. Díaz-Ortíz
A mild, clean, practical, sustainable and high yielding procedure for Suzuki–Miyaura crosscoupling in a single pass using a silica-supported palladium catalyst is described. The catalyst can be used in more than 30 reactions and for more than 8 h of continuous processing without a decrease in reactivity due to the low leaching observed. Different halides/pseudo-halides and organoboron compounds can be used without modifying the standard procedure.