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Insulin and bone health in young adults: the mediator role of lean mass

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dc.contributor.author Torres Costoso, Ana Isabel
dc.contributor.author Pozuelo Carrascosa, Diana P.
dc.contributor.author Álvarez Bueno, Celia
dc.contributor.author Ferri Morales, Asunción
dc.contributor.author Miota Ibarra, José
dc.contributor.author Notario Pacheco, Blanca
dc.contributor.author Martínez Vizcaíno, Vicente
dc.date.accessioned 2017-03-29T09:21:03Z
dc.date.available 2017-03-29T09:21:03Z
dc.date.issued 2017
dc.identifier.citation PLoS ONE. 2017.03.21 es_ES
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10578/13412
dc.description.abstract Background: The positive relationship between lean mass (LM) and bone health is well known, but a positive association between insulin and LM has also been described. Insulin has some anabolic properties on bone through the stimulation of osteoblast differentiation, yet the role of LM as a confounder or mediator in this relationship remains uncertain. Objective: To examine whether the association between insulin levels and bone health is mediated by LM. Methods: A cross-sectional study was conducted at the Castilla La Mancha University (Spain) involving 466 young adults (113 young men; 19.5±2.3 years). LM and total-body bone mineral content (BMC) were measured by dual energy x-ray absorptiometry, and insulin was measured in fasting serum samples. Results: Young adults with high total LM had higher values of total-body BMC than their peers after controlling for age and sex, this relationship persisted after adjusting for insulin levels (p<0.001). In mediation analyses, insulin levels were positively associated with total-body BMC (b = 0.05; p<0.001) and total LM acted as an intermediate variable, attenuating the association between insulin levels and total-body BMC (b = -31.98; p>0.05) as indicated by Sobel test values for indirect effect (z = 4.43; p<0.001). Conclusions: LM plays an important role in the relationship between insulin levels and bone health, in such a way that while increases in LM have a positive influence on bone health, they are also negatively associated with insulin levels. es_ES
dc.format application/pdf es_ES
dc.language.iso en es_ES
dc.rights info:eu-repo/semantics/openAccess es_ES
dc.subject Yount Adult es_ES
dc.subject Insuline es_ES
dc.subject Bone and Bones es_ES
dc.subject Osteoblasts es_ES
dc.title Insulin and bone health in young adults: the mediator role of lean mass es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.DOI 10.1371/journal.pone.0173874

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