Computerized evaluation of mean residence times in multicom-partmental linear system and pharmacokinetics

Abstract

Taking as start point the analysis of the mean residence times in multicompartmental linear systems open or closed, we implement a versatile software, using the VISUAL BASIC 6.0 language, that is easy to use and with a user-friendly format for the input of data and the output of the results. For any multicompartmental linear system of up to 512 compartments, closed or open, with traps or without traps, with zero input in one or more of the compartments, this software allows the user to obtain, both the symbolic expressions, in the most simplified form, and/or the numerical values of the mean residence times in any of its compartments, in the entire system or in a part of the system. As far as we known from the literature, such a software has not been implemented before. The advantage of the present software is that it cuts down on the work time needed and minimizes the human errors that are frequent in compartmental systems even those that are relatively staightforward. The software bioCelTer, along with instructions, can be downloaded from http://oretano.iele ab.uclm.es/~fgarcia/bioCelTer/