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Effects of aerobic interval training on arterial stiffness and microvascular function of metabolic syndrome subjects

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dc.contributor.author Mora-Rodríguez, Ricardo
dc.contributor.author Ramirez-Jimenez, Miguel
dc.contributor.author Fernández-Elías, Valentín Emilio
dc.contributor.author Guío de Prada, María Victoria
dc.contributor.author G. Pallares, Jesus
dc.contributor.author Nelson, Rachael
dc.contributor.author Ortega, Juan Fernando
dc.date.accessioned 2018-03-14T15:59:18Z
dc.date.available 2018-03-14T15:59:18Z
dc.date.issued 2018
dc.identifier.citation Journal of Clinical Hypertension. 2018, (20), 11-18 es_ES
dc.identifier.issn 1524-6175
dc.identifier.uri http://hdl.handle.net/10578/16732
dc.description.abstract We determined the effect of high-intensity aerobic interval training on arterial stiffness and microvascular dysfunction in metabolic syndrome patients (MetS) with hypertension. We used applanation tonometry to measure arterial stiffness and laser Doppler flowmetry to assess microvascular dysfunction before and after 6 months of stationary cycling (TRAIN group; N=23) in comparison to a group that remained sedentary (CONT group; N=23). While no variable improved in CONT, in the TRAIN group hypertension rate fell from 79% (59-91%) to 41% (24-61%) resulting in lower systolic and diastolic pressures than CONT (-12±3 and - 6±2 mmHg; P < 0.008). Arterial stiffness declined (-17% augmentation index; P = 0.048) and reactive hyperemia increased (20%; P = 0.028) post –treatment in TRAIN vs. CONT. Blood constituents associated with arterial stiffness and with prothrombotic state (high-sensitive C-reactive protein, fibrinogen, platelets and erythrocytes) remained unchanged in TRAIN and CONT groups. In summary, six-month of intense aerobic exercise program reduces both arterial stiffness and microvascular dysfunction in MetS patients despite unchanged blood borne cardiovascular risk factors. Training lowers blood flow resistance in central and peripheral vascular beds in a coordinated fashion resulting in clinically relevant reductions in hypertension. es_ES
dc.format text/plain es_ES
dc.language.iso en es_ES
dc.publisher Willey es_ES
dc.rights info:eu-repo/semantics/openAccess es_ES
dc.subject Physical fitness es_ES
dc.subject Aptitud física es_ES
dc.subject Metabolic syndrome X es_ES
dc.subject Síndrome metabólico X es_ES
dc.subject Vascular stiffness es_ES
dc.subject Rigidez vascular es_ES
dc.subject Pulse wave velocity es_ES
dc.subject Velocidad de la onda de pulso es_ES
dc.subject Reactive hyperemia es_ES
dc.subject Hiperemia reactiva es_ES
dc.title Effects of aerobic interval training on arterial stiffness and microvascular function of metabolic syndrome subjects es_ES
dc.type info:eu-repo/semantics/article es_ES


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