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Infection-derived lipids elicit an immune deficiency circuit in arthropods

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dc.contributor.author Margarita M. Villar-Rayo
dc.contributor.author José de la Fuente
dc.date.accessioned 2018-03-23T11:12:12Z
dc.date.available 2018-03-23T11:12:12Z
dc.date.issued 2017-02-14
dc.identifier.citation SHAW, DANA K., WANG, XIAOWEI, BROWN, LINDSEY J., CHÁVEZ, ADELA S. OLIVA, REIF, KATHRYN E., SMITH, ALEXIS A., SCOTT, ALISON J., MCCLURE, ERIN E., BORADIA, VISHANT M., HAMMOND, HOLLY L., SUNDBERG, ERIC J., SNYDER, GREG A., LIU, LEI, DEPONTE, KATHLEEN, VILLAR, MARGARITA, UETI, MASSARO W., DE LA FUENTE, JOSÉ, ERNST, ROBERT K., PAL, UTPAL, FIKRIG, EROL and PEDRA, JOAO H. F., 2017, Infection-derived lipids elicit an immune deficiency circuit in arthropods. Nature Communications. 2017. Vol. 8, p. 14401. DOI 10.1038/ncomms14401. Springer Nature es_ES
dc.identifier.issn 2041-1723
dc.identifier.uri http://hdl.handle.net/10578/16816
dc.description.abstract The insect immune deficiency (IMD) pathway resembles the tumour necrosis factor receptor network in mammals and senses diaminopimelic-type peptidoglycans present in Gram-negative bacteria. Whether unidentified chemical moieties activate the IMD signalling cascade remains unknown. Here, we show that infection-derived lipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) and 1-palmitoyl-2-oleoyl diacylglycerol (PODAG) stimulate the IMD pathway of ticks. The tick IMD network protects against colonization by three distinct bacteria, that is the Lyme disease spirochete Borrelia burgdorferi and the rickettsial agents Anaplasma phagocytophilum and A. marginale. Cell signalling ensues in the absence of transmembrane peptidoglycan recognition proteins and the adaptor molecules Fas-associated protein with a death domain (FADD) and IMD. Conversely, biochemical interactions occur between x-linked inhibitor of apoptosis protein (XIAP), an E3 ubiquitin ligase, and the E2 conjugating enzyme Bendless. We propose the existence of two functionally distinct IMD networks, one in insects and another in ticks. es_ES
dc.format text/plain es_ES
dc.language.iso en es_ES
dc.publisher Spring Nature es_ES
dc.rights info:eu-repo/semantics/closedAccess es_ES
dc.subject Bioquímica es_ES
dc.title Infection-derived lipids elicit an immune deficiency circuit in arthropods es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.DOI 10.1038/ncomms14401

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