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Association between pre-pregnancy overweight and obesity and children's neurocognitive development: a systematic review and meta-analysis of observational studies.

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dc.contributor.author Álvarez Bueno, Celia
dc.contributor.author Cavero Redondo, Iván
dc.contributor.author Lucas de la Cruz, Lidia
dc.contributor.author Notario Pacheco, Blanca
dc.contributor.author Martínez Vizcaíno, Vicente
dc.date.accessioned 2018-04-09T12:04:21Z
dc.date.available 2018-04-09T12:04:21Z
dc.date.issued 2017
dc.identifier.citation International Journal of Epidemiology. 2017, 46(5), 1667 es_ES
dc.identifier.issn 1653-1666
dc.identifier.uri http://hdl.handle.net/10578/16991
dc.description.abstract Background Obesity and overweight during pregnancy have been negatively associated with fetal and offspring neurodevelopment. The aim of this systematic review and meta-analysis was to assess the effect of the relationship between pre-pregnancy overweight and obesity with children’s neurocognitive development. Methods We systematically searched MEDLINE, EMBASE, the Cochrane Library and the Web of Science databases from their inception through February 2017 for follow-up studies comparing the relationship between pre-pregnancy weight status and children’s cognition. The Mantel-Haenszel fixed-effects method was used to calculate pooled effect size (ES) values and their corresponding 95% confidence intervals (CIs) comparing children’s neurocognitive development between pre-pregnancy normal weight, as reference, with overweight and obesity categories. Results Fifteen articles were included in the systematic review, and nine of them in the meta-analysis. The pooled ES values for overweight and obese mothers were −0.02 (95% CI: −0.05 to 0.02) and −0.06 (95% CI: −0.09 to −0.03), respectively. The pooled ES for the relationship between pre-gestational excess weight (overweight and obesity) and children’s neurocognitive development was −0.04 (95% CI: −0.06 to −0.02). Conclusions Pre-pregnancy obesity might have negative consequences on the neurocognitive development of offspring es_ES
dc.format application/pdf es_ES
dc.language.iso en es_ES
dc.publisher Oxford Academic es_ES
dc.rights info:eu-repo/semantics/openAccess es_ES
dc.subject Pregnancy es_ES
dc.subject Obesity es_ES
dc.subject Children es_ES
dc.subject Cognition es_ES
dc.subject Cognitive function es_ES
dc.subject Neurocognitive development es_ES
dc.title Association between pre-pregnancy overweight and obesity and children's neurocognitive development: a systematic review and meta-analysis of observational studies. es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.DOI https://doi.org/10.1093/ije/dyx122


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