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Functional evolution of Subolesin/Akirin.

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dc.contributor.author Artigas-Jerónimo, S.
dc.contributor.author Margarita M. Villar-Rayo
dc.contributor.author Cabezas-Cruz, Alejandro
dc.contributor.author Valdés, James J.
dc.contributor.author Estrada-Peña, Agustín
dc.date.accessioned 2019-09-27T09:13:35Z
dc.date.available 2019-09-27T09:13:35Z
dc.date.issued 2019-11-13
dc.identifier.citation Artigas-Jerónimo, S., Villar, M., Cabezas-Cruz, A., Valdes, J. J., Estrada-Peña, A., Alberdi, P., & De La Fuente, J. (2018). Functional evolution of subolesin/akirin. Frontiers in physiology, 9, 1612. es_ES
dc.identifier.issn 1664-042X
dc.identifier.uri http://hdl.handle.net/10578/21960
dc.description.abstract The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent results on their structure, protein-protein interactions and function in different species to provide insights into the functional evolution of these regulatory proteins, and their potential as vaccine antigens for the control of ectoparasite infestations and pathogen infection. The results suggest that Subolesin/Akirin evolved conserving not only its sequence and structure, but also its function and role in cell interactome and regulome in response to pathogen infection and other biological processes. This functional conservation provides a platform for further characterization of the function of these regulatory proteins, and how their evolution can meet species-specific demands. Furthermore, the conserved functional evolution of Subolesin/Akirin correlates with the protective capacity shown by these proteins in vaccine formulations for the control of different arthropod and pathogen species. These results encourage further research to characterize the structure and function of these proteins, and to develop new vaccine formulations by combining Subolesin/Akirin with interacting proteins for the control of multiple ectoparasite infestations and pathogen infection. es_ES
dc.format application/pdf es_ES
dc.language.iso en es_ES
dc.publisher Frontiers es_ES
dc.rights info:eu-repo/semantics/openAccess es_ES
dc.subject immune response es_ES
dc.subject vaccine es_ES
dc.subject interactome es_ES
dc.subject regulome es_ES
dc.subject phylogeny es_ES
dc.subject tick es_ES
dc.subject Anaplasma phagocytophilum es_ES
dc.title Functional evolution of Subolesin/Akirin. es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.DOI 10.3389/fphys.2018.01612


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