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Tick-pathogen interactions: the metabolic perspective.

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dc.contributor.author Artigas Jerónimo, Sara
dc.contributor.author Estrada Peña, Agustín
dc.contributor.author Cabezas Cruz, Alejandra
dc.contributor.author Alberdi, PIlar
dc.contributor.author Margarita M. Villar Rayo
dc.contributor.author José de la Fuente
dc.date.accessioned 2020-01-10T11:50:44Z
dc.date.available 2020-01-10T11:50:44Z
dc.date.issued 2019-04-18
dc.identifier.citation Cabezas-Cruz, A., Espinosa, P., Alberdi, P., & de la Fuente, J. (2019). Tick–Pathogen Interactions: The Metabolic Perspective. Trends in parasitology. es_ES
dc.identifier.uri http://hdl.handle.net/10578/23039
dc.description.abstract The first tick genome published in 2016 provided an invaluable tool for studying the molecular basis of tick–pathogen interactions. Metabolism is a key element in host–pathogen interactions. However, our knowledge of tick–pathogen metabolic interactions is very limited. Recently, a systems biology approach, using omics datasets, has revealed that tick-borne pathogen infection induces transcriptional reprograming affecting several metabolic pathways in ticks, facilitating infection, multiplication, and transmission. Results suggest that the response of tick cells to tick-borne pathogens is associated with tolerance to infection. Here we review our current understanding of the modulation of tick metabolism by tick-borne pathogens, with a focus on the model intracellular bacterium Anaplasma phagocytophilum. es_ES
dc.format application/pdf es_ES
dc.language.iso en es_ES
dc.rights info:eu-repo/semantics/closedAccess es_ES
dc.subject Tick-pathogen es_ES
dc.subject Anaplasma phagocytophilum es_ES
dc.title Tick-pathogen interactions: the metabolic perspective. es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.DOI 10.1016/j.pt.2019.01.006


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