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A novel combined scientific and artistic approach for advanced characterization of interactomes:

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Date
2020-02-08
Author
Artigas Jerónimo, Sara
Pastor Comín, Juán José
Villar Rayo, Margarita M.
Contreras Rojo, Marinela
Alberdi, Pilar
León Viera, Israel
Soto, Leandro
Cordero, Raúl
Valdés, James J.
Cabezas Cruz, Alejandro
Estrada Peña, Agustín
De la Fuente, José
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Abstract
The main objective of this study was to propose a novel methodology to approach challenges in molecular biology. Akirin/Subolesin (AKR/SUB) are vaccine protective antigens and are a model for the study of the interactome due to its conserved function in the regulation of different biological processes such as immunity and development throughout the metazoan. Herein, three visual artists and a music professor collaborated with scientists for the functional characterization of the AKR2 interactome in the regulation of the NF-?B pathway in human placenta cells. The results served as a methodological proof-of-concept to advance this research area. The results showed new perspectives on unexplored characteristics of AKR2 with functional implications. These results included protein dimerization, the physical interactions with different proteins simultaneously to regulate various biological processes defined by cell type-specific AKR-protein interactions, and how these interactions positively or negatively regulate the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) signaling pathway in a biological context-dependent manner. These results suggested that AKR2-interacting proteins might constitute suitable secondary transcription factors for cell- and stimulus-specific regulation of NF-?B. Musical perspective supported AKR/SUB evolutionary conservation in different species and provided new mechanistic insights into the AKR2 interactome. The combined scientific and artistic perspectives resulted in a multidisciplinary approach, advancing our knowledge on AKR/SUB interactome, and provided new insights into the function of AKR2-protein interactions in the regulation of the NF-?B pathway. Additionally, herein we proposed an algorithm for quantum vaccinomics by focusing on the model proteins AKR/SUB.
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http://hdl.handle.net/10578/27383
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© Universidad de Castilla-La Mancha
Rectorado
C/ Altagracia, 50 13071
Ciudad Real Tfno. 926 29 53 00
Fax: 926 29 53 01

Copyright | Documentation | Other Resources | Contact Us
Ruidera

¿RUIdeRA?

Federcc
DSpace