Departamento de Ciencias Médicas
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Dorsoventral Arrangement of Lateral Hypothalamus Populations in the Mouse Hypothalamus: a Prosomeric Genoarchitectonic Analysis
(Springer, 2023)The lateral hypothalamus (LH) has a heterogeneous cytoarchitectonic organization that has not been elucidated in detail. In this work, we analyzed within the framework of the prosomeric model the diferential expression ... -
The caveolae‐associated coiled‐coil protein, NECC2, regulates insulin signalling in Adipocytes
(Wiley Open Access, 2018-08)Adipocyte dysfunction in obesity is commonly associated with impaired insulin signalling in adipocytes and insulin resistance. Insulin signalling has been associated with caveolae, which are coated by large complexes of ... -
Assessment of Genotoxicity Induced by Subchronic Exposure to Graphene in HaCaT Human Skin Cell Line
(Taylor & Francis, 2022)The applications of graphene-based materials (GBMs) and even their processing involve prolonged contact with cellular barriers such as human skin. Even though the potential cytotoxicity of graphene has been studied in ... -
El cuerpo desnudo en los escenarios de la Segunda República: liberación o cosificación de la mujer. Una aproximación a través de la obra La pipa de oro
(ADHUC—Centre de Recerca Teoria, Gènere, Sexualitat (Universitat de Barcelona), 2022-04)A principios del siglo XX, en un contexto de creciente erotización de la cultura, los espectáculos teatrales asistieron a los primeros desnudos femeninos. En el presente ensayo se analiza el papel del cuerpo de la mujer ... -
Aberrations of Genomic Imprinting in Glioblastoma Formation
(Frontiers, 2021)In human glioblastoma (GBM), the presence of a small population of cells with stem cell characteristics, the glioma stem cells (GSCs), has been described. These cells have GBM potential and are responsible for the origin ... -
Pan-BCL2 family inhibitor obatoclax as treatment for parental and cisplatin-resistant triple negative breast cancer
(European Organisation for Research and Treatment of Cancer, 2020)Triple negative breast cancer (TNBC) is an incurable disease where novel therapeutic strategies are needed. Nowadays, only chemotherapy and radi otherapy are standard treatments for TNBC. Cancer stem cells population (CSCs) ... -
Neurodegeneration and astrogliosis in the entorhinal cortex in Alzheimer’s disease: Stereological layer-specific assessment and proteomic analysis
(Wiley, 2022-02)Introduction: The entorhinal cortex is among the earliest areas involved in Alzheimer’s disease. Volume reduction and neural loss in this area have been widely reported. Human entorhinal cortex atrophy is, in part, due ... -
Laparoscopic versus laparotomy approach to endometrial cancer: A prospective study
(Publicación de investigación científica, 2013-06)Objective: The aim of this study was to compare laparoscopic (LPS) and laparotomy (LPT) approaches for endometrial cancer, and to assess intraoperative and postoperative results, disease-free survival and overall survival. ... -
Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
(Elsevier, 2021-11)This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and ... -
Subchronic Graphene Exposure Reshapes Skin Cell Metabolism
(ACS, 2022-05)In recent years, the toxicity of graphene-related materials (GRMs) has been evaluated in diverse models to guarantee their safety. In most applications, sublethal doses of GRMs contact human barriers such as skin in a ... -
Importance of Lactic Acid in Maintaining Vaginal Health: A Review of Vaginitis and Vaginosis Etiopathogenic Bases and a Proposal for a New Treatment
(Scientific Research Publishing, 2014-08-29)The most frequent cause of visits to the gynecologist in the western world is vaginal discomfort (vaginitis and vaginosis) whose origin lies in the uncontrolled proliferation of bacteria, such as haemophilus vaginalis or ... -
One-Step Nucleic Acid Amplification (OSNA) of Sentinel Lymph Node in Early-Stage Endometrial Cancer: Spanish Multicenter Study (ENDO-OSNA)
(MDPI, 2021-09-04)The objective of this study was to evaluate the efficacy of one-step nucleic acid amplification (OSNA) for the detection of sentinel lymph node (SLN) metastasis compared to standard pathological ultrastaging in patients ... -
Rapid and efficient testing of the toxicity of graphene-related materials in primary human lung cells
(Nature, 2022-05)Graphene and its derivative materials are manufactured by numerous companies and research laboratories, during which processes they can come into contact with their handlers' physiological barriers—for instance, their ... -
Cuprizone-Induced Neurotoxicity in Human Neural Cell Lines Is Mediated by a Reversible Mitochondrial Dysfunction: Relevance for Demyelination Models
(MDPI, 21-02-22)Suitable in vivo and in vitro models are instrumental for the development of new drugs aimed at improving symptoms or progression of multiple sclerosis (MS). The cuprizone (CPZ)-induced murine model has gained momentum in ... -
Loss of One Engrailed1 Allele Enhances Induced α-Synucleinopathy
(IOS Press, 2019-05-23)Parkinson’s disease (PD) is a synucleinopathy that has multiple neuropathological characteristics, with nigrostriatal dopamine system degeneration being a core feature. Current models of PD pathology typically fail to ... -
Endometrial study in patients with postmenopausal metrorrhagia
(Termedia & Banach, 2016)Introduction: The aim of the study was to devise a strategy to diagnose malign endometrial pathologies (adenocarcinoma or atypical hyperplasia) that minimizes the number of invasive tests done (hysteroscopy, aspiration ... -
Impact of Metformin on Cancer Biomarkers in Non-Diabetic Cancer Patients: A Systematic Review and Meta-Analysis of Clinical Trials
(MDPI, 2021-04-06)Introduction: Our aim was to investigate and evaluate the influence of metformin on cancer-related biomarkers in clinical trials. Methods: This systematic study was conducted according to Preferred Reporting Items for ... -
Neurological Symptoms of COVID-19: The Zonulin Hypothesis
(Frontiers, 2021-04)The irruption of SARS-CoV-2 during 2020 has been of pandemic proportions due to its rapid spread and virulence. COVID-19 patients experience respiratory, digestive and neurological symptoms. Distinctive symptom as anosmia, ... -
CATÁLOGO RAZONADO DE LA COLECCIÓN DE PIEZAS ANATÓMICAS DEL MUSEO DE SANIDAD E HIGIENE PÚBLICA
(INSTITUTO DE SALUD CARLOS III, 2017-05)Como responsable del Servicio de Anatomía Patológica del Hospital Universitario La Paz-Hospital de Cantoblanco-Hospital Carlos III, heredero de las mejores tradiciones de la Anatomía Patológica española, es para mí un ... -
Decision tree learning to predict overweight/obesity based on body mass index and gene polymporphisms
(Elsevier, 2019-05)The new technologies for data analysis, such as decision tree learning, may help to predict the risk of developing diseases. The aim of the present work was to develop a pilot decision tree learning to predict overweight/obesity ...
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