Departamento de Ciencias Médicas
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Laparoscopic versus laparotomy approach to endometrial cancer: A prospective study
(Publicación de investigación científica, 2013-06)Objective: The aim of this study was to compare laparoscopic (LPS) and laparotomy (LPT) approaches for endometrial cancer, and to assess intraoperative and postoperative results, disease-free survival and overall survival. ... -
Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
(Elsevier, 2021-11)This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and ... -
Subchronic Graphene Exposure Reshapes Skin Cell Metabolism
(ACS, 2022-05)In recent years, the toxicity of graphene-related materials (GRMs) has been evaluated in diverse models to guarantee their safety. In most applications, sublethal doses of GRMs contact human barriers such as skin in a ... -
Importance of Lactic Acid in Maintaining Vaginal Health: A Review of Vaginitis and Vaginosis Etiopathogenic Bases and a Proposal for a New Treatment
(Scientific Research Publishing, 2014-08-29)The most frequent cause of visits to the gynecologist in the western world is vaginal discomfort (vaginitis and vaginosis) whose origin lies in the uncontrolled proliferation of bacteria, such as haemophilus vaginalis or ... -
One-Step Nucleic Acid Amplification (OSNA) of Sentinel Lymph Node in Early-Stage Endometrial Cancer: Spanish Multicenter Study (ENDO-OSNA)
(MDPI, 2021-09-04)The objective of this study was to evaluate the efficacy of one-step nucleic acid amplification (OSNA) for the detection of sentinel lymph node (SLN) metastasis compared to standard pathological ultrastaging in patients ... -
Rapid and efficient testing of the toxicity of graphene-related materials in primary human lung cells
(Nature, 2022-05)Graphene and its derivative materials are manufactured by numerous companies and research laboratories, during which processes they can come into contact with their handlers' physiological barriers—for instance, their ... -
Cuprizone-Induced Neurotoxicity in Human Neural Cell Lines Is Mediated by a Reversible Mitochondrial Dysfunction: Relevance for Demyelination Models
(MDPI, 21-02-22)Suitable in vivo and in vitro models are instrumental for the development of new drugs aimed at improving symptoms or progression of multiple sclerosis (MS). The cuprizone (CPZ)-induced murine model has gained momentum in ... -
Loss of One Engrailed1 Allele Enhances Induced α-Synucleinopathy
(IOS Press, 2019-05-23)Parkinson’s disease (PD) is a synucleinopathy that has multiple neuropathological characteristics, with nigrostriatal dopamine system degeneration being a core feature. Current models of PD pathology typically fail to ... -
Endometrial study in patients with postmenopausal metrorrhagia
(Termedia & Banach, 2016)Introduction: The aim of the study was to devise a strategy to diagnose malign endometrial pathologies (adenocarcinoma or atypical hyperplasia) that minimizes the number of invasive tests done (hysteroscopy, aspiration ... -
Impact of Metformin on Cancer Biomarkers in Non-Diabetic Cancer Patients: A Systematic Review and Meta-Analysis of Clinical Trials
(MDPI, 2021-04-06)Introduction: Our aim was to investigate and evaluate the influence of metformin on cancer-related biomarkers in clinical trials. Methods: This systematic study was conducted according to Preferred Reporting Items for ... -
Neurological Symptoms of COVID-19: The Zonulin Hypothesis
(Frontiers, 2021-04)The irruption of SARS-CoV-2 during 2020 has been of pandemic proportions due to its rapid spread and virulence. COVID-19 patients experience respiratory, digestive and neurological symptoms. Distinctive symptom as anosmia, ... -
CATÁLOGO RAZONADO DE LA COLECCIÓN DE PIEZAS ANATÓMICAS DEL MUSEO DE SANIDAD E HIGIENE PÚBLICA
(INSTITUTO DE SALUD CARLOS III, 2017-05)Como responsable del Servicio de Anatomía Patológica del Hospital Universitario La Paz-Hospital de Cantoblanco-Hospital Carlos III, heredero de las mejores tradiciones de la Anatomía Patológica española, es para mí un ... -
Decision tree learning to predict overweight/obesity based on body mass index and gene polymporphisms
(Elsevier, 2019-05)The new technologies for data analysis, such as decision tree learning, may help to predict the risk of developing diseases. The aim of the present work was to develop a pilot decision tree learning to predict overweight/obesity ... -
Documentación fotográfica de la colección de piezas anatómicas del Museo de Sanidad e Higiene Pública del Instituto de Salud Carlos III (catálogo razonado).
(INSTITUTO DE SALUD CARLOS III, 2018)Hace unos años tuve la oportunidad de visitar la colección de piezas anatómicas y fotografías del Museo de Sanidad e Higiene Pública del Instituto de Salud Carlos III, procedentes de las autopsias realizadas en el antiguo ... -
Hippocampal long-term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G-protein-gated inwardly rectifying potassium channel activity
(WileyInternational Society for Neurochemistry, 2019-12-20)Hippocampal synaptic plasticity disruption by amyloid-β (Aβ) peptides + thought to be responsible for learning and memory impairments in Alzheimer's disease (AD) early stage. Failures in neuronal excitability maintenance ... -
A comprehensive systematic review of CSF proteins and peptides that defne Alzheimer’s disease
(BMC, 2020-06-05)Background: During the last two decades, over 100 proteomics studies have identifed a variety of potential bio‑ markers in CSF of Alzheimer’s (AD) patients. Although several reviews have proposed specifc biomarkers, to ... -
Pathogenic Microenvironment from Diabetic–Obese Visceral and Subcutaneous Adipocytes Activating Differentiation of Human Healthy Preadipocytes Increases Intracellular Fat, Effect of the Apocarotenoid Crocetin
(MDPI, 2021-03-23)In diabetes mellitus type 2 (DM2), developed obesity is referred to as diabesity. Implementation of a healthy diet, such as the Mediterranean, prevents diabesity. Saffron is frequently used in this diet because of its ... -
The bacteriostatic effect of controlled-flux electrolyzed acidic solution on healthy hallucal skin
(ElsevierTissue Viability Society, 2019-10-23)Background: There are various treatment protocols to manage the increased bacterial load in plantar ulcers. Recently, Controlled-Flux Electrolyzed Acidic Solution (CFEAS), with a pH less than 3, has appeared to be ... -
Importance of Footwear for Preventing Xerosis and Hyperkeratosis in Older People with Psychiatric Disorders Living in an Institution
(MDPI, 2018-03-24)Few studies have focused on the relation between the use and characteristics of footwear and the presence of foot lesions in people with psychiatric disorders. This work analyzes the influence of different footwear habits ... -
Molecular characterization of contact urticaria in patients with melon allergy
(Wiley, 2013-10-21)The relevance of contact allergy to plant-related food has recently emerged. Oral allergy syndrome is one of the most characteristic symptoms of fruit allergy, although it also causes systemic reactions. Plant-food allergy ...
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