Área de Histología
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Dorsoventral Arrangement of Lateral Hypothalamus Populations in the Mouse Hypothalamus: a Prosomeric Genoarchitectonic Analysis
(Springer, 2023)The lateral hypothalamus (LH) has a heterogeneous cytoarchitectonic organization that has not been elucidated in detail. In this work, we analyzed within the framework of the prosomeric model the diferential expression ... -
LacZ-reporter mapping of Dlx5/6 expression and genoarchitectural analysis of the postnatal mouse prethalamus
(Wiley & Sons, 2020-05-18)We present here a thorough and complete analysis of mouse P0-P140 prethalamic histogenetic subdivisions and corresponding nuclear derivatives, in the context of local tract landmarks. The study used as fundamental material ... -
Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity
(CellPress, 2020-03)Dopamine is involved in physiological processes like learning and memory, motor control and reward, and pathological conditions such as Parkinson’s disease and addiction. In contrast to the extensive studies on neurons, ... -
Adenosine A2A-cannabinoid CB1 receptor heteromers in the hippocampus: cannabidiol Δ9-tetrahydrocannabinol-induced cognitive impairment
(Springer, 2019-01-04)At present, clinical interest in the plant-derived cannabinoid compound cannabidiol (CBD) is rising exponentially, since it displays multiple therapeutic properties. In addition, CBD can counteract the undesirable effects ... -
Circuit-specific control of the medial entorhinal inputs to the dentate gyrus by atypical presynaptic NMDARs activated by astrocytes
(PNAS, 2019-05-05)Here, we investigated the properties of presynaptic N-methyl-Daspartate receptors (pre-NMDARs) at corticohippocampal excitatory connections between perforant path (PP) afferents and dentate granule cells (GCs), a circuit ... -
Reduction in the neuronal surface of post and presynaptic GABAB receptors in the hippocampus in a mouse model of Alzheimer’s disease
(Wiley, 2019-11-15)The hippocampus plays key roles in learning and memory and is a main target of Alzheimer’s disease (AD), which causes progressive memory impairments. Despite numerous investigations about the processes required for the ... -
Sensory neuron–derived NaV1.7 contributes to dorsal horn neuron excitability
(American Association for the Advancement of Science, 2020)Expression of the voltage-gated sodium channel NaV1.7 in sensory neurons is required for pain sensation. We examined the role of NaV1.7 in the dorsal horn of the spinal cord using an epitope-tagged NaV1.7 knock-in ... -
Excitotoxic targeting of Kidins220 to the Golgi apparatus precedes calpain cleavage of Rap1-activation complexes
(Springer Nature.CDD Press, 2019)Excitotoxic neuronal death induced by high concentrations of glutamate is a pathological event common to multiple acute or chronic neurodegenerative diseases. Excitotoxicity is mediated through overactivation of the ... -
Expression, Cellular and Subcellular Localisation of Kv4.2 and Kv4.3 Channels in the Rodent Hippocampus
(MDPI, 2019-01-09)The Kv4 family of voltage-gated K+ channels underlie the fast transient (A-type) outward K+ current. Although A-type currents are critical to determine somato-dendritic integration in central neurons, relatively little ... -
Differential association of GABAB receptors with their effector ion channels in Purkinje cells
(Springer, 2017-11-25)Metabotropic GABAB receptors mediate slow inhibitory effects presynaptically and postsynaptically through the modulation of different effector signalling pathways. Here, we analysed the distribution of GABAB receptors using ... -
Cellular and Subcellular Localization of the RGS7/Gβ5/R7BP Complex in the Cerebellar Cortex
(Frontiers Media, 2016-11-30)A member of regulator of G-protein signaling family, RGS7, is an essential modulator of signaling through GABAB receptors. RGS7 functions as a macromolecular complex with type 5 G protein β (Gβ5) and R7 binding protein ... -
Ontogenic Changes and Differential Localization of T-type Ca2+ Channel Subunits Cav3.1 and Cav3.2 in Mouse Hippocampus and Cerebellum
(Frontiers Media, 2016-08)T-type calcium (Ca2+) channels play a central role in regulating membrane excitability in the brain. Although the contributions of T-type current to neuron output is often proposed to reflect a differential distribution ... -
GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons
(Nature, 2018)Human mutations of the GRID1 gene encoding the orphan delta1 glutamate receptor-channel (GluD1) are associated with schizophrenia but the explicit role of GluD1 in brain circuits is unknown. Based on the known function of ... -
HCN1 channels reduce the rate of exocytosis from a subset of cortical synaptic terminals
(Nature, 2017-01-10)The hyperpolarization-activated cyclic nucleotide-gated (HCN1) channels are predominantly located in pyramidal cell dendrites within the cortex. Recent evidence suggests these channels also exist presynaptically in a subset ... -
The Parkinson’s disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo
(Nature, 2017-08)G protein-coupled receptor 37 (GPR37) is an orphan receptor associated to Parkinson’s disease (PD) neuropathology. Here, we identifed GPR37 as an inhibitor of adenosine A2A receptor (A2AR) cell surface expression and ... -
Monitoring the colonization and infection of legume nodules by Micromonospora in co-inoculation experiments with rhizobia
(Springer nature, 2017-09-08)The discovery that the actinobacterium Micromonospora inhabits nitrogen-fixing nodules raised questions as to its potential ecological role. The capacity of two Micromonospora strains to infect legumes other than their ... -
Fate-mapping the mammalian hindbrain: segmental origins of vestibular projection neurons assessed using rhombomere-specific hoxa2 enhancer elements in the mouse embryo.
(Society for Neuroscience, 2007)As a step toward generating a fate map of identified neuron populations in the mammalian hindbrain, we assessed the contributions of individual rhombomeres to the vestibular nuclear complex, a major sensorimotor area that ... -
Regionalized differentiation of crh, trh and ghrh peptidergic neurons in the mouse hypothalamus
(Springer, 2014)According to the updated prosomeric model, the hypothalamus is subdivided rostrocaudally into terminal and peduncular parts, and dorsoventrally into alar, basal, and floor longitudinal zones. In this context, we examined ... -
Topography of somatostatin gene expression relative to molecular progenitor domains during ontogeny of the mouse hypothalamus
(2011)The hypothalamus comprises alar, basal, and floor plate developmental compartments. Recent molecular data support a rostrocaudal subdivision into rostral (terminal) and caudal (peduncular) halves. In this context, the ...
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