Recent Submissions

  • Genomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans 

    Rodrigues-Soares, Fernanda; Peñas-Lledó, Eva; Tarazona, Eduardo; Sosa-Macías, Martha; Terán, Enrique; López-López, Marisol; Rodeiro Guerra, Idania; Moya, Graciela; Calzadilla, Luis R.; Ramírez-Roa, Ronald; Grazina, Manuela; Estévez-Carrizo, Francisco E.; Barrantes-Reynolds, Ramiro; Llerena, A.; Altamirano-Tinoco, Catalina; Alvárez, Mayra; Borbón Orjuela, Angélica Rocío; Céspedes-Garro, Carolina; Cobaleda, Jesús; Andrés, F. de; Delgado, René; Dorado, Pedro; Fariñas, Humberto; Ferreiro, Verónica; Fricke-Galindo, Ingrid; Galaviz-Hernández, Carlos; Garza Ocañas, Lourdes; Gilman, Robert H.; Hernández, Francisco; Jíménez-Arce, Gerardo; Jung-Cook, Helgi; Lares-Aseff, Ismael; Lazalde-Ramos, Blanca Patricia; Michelin, Lucas; Monroy-Jaramillo, Nancy; Gómez Naranjo, María Eugenia; Ortega-Vázquez, Alberto; Ortiz-López, Rocío; Pérez, Bárbaro; Pérez-Páramo, Yadira Xitlalli; Remirez, Diadelis; Rojas-Martínez, Augusto; Sarmiento, Alba Piedad; Scliar, Marilia; Terán, Santiago; Zamudio Zea, Roxana (American Society for Clinical Pharmacology and Therapeutics, 2019)
    We present the distribution of CYP2D6, CYP2C9, and CYP2C19 variants and predicted phenotypes in 33 native and admixed populations from Ibero-America (n > 6,000) in the context of genetic ancestry (n = 3,387). Continenta ...
  • Clinical implementation of pharmacogenetics and personalized drug prescription based on e-health: the MedeA initiative 

    Llerena, A.; Peñas-Lledó, Eva; Andrés, F. de; Mata-Martín, Carmen; Sánchez, Cristina L.; Pijierro, Agustín; Cobaleda, Jesús (De Gruyter, 2020)
    There is a growing demand for the clinical implementation of pharmacogenetics (PGx), personalized and precision medicine (PPM) for drug prescription to reduce adverse drug reactions (ADRs), drug failure, and ultimately ...
  • Frequency of CYP2C9 (*2, *3 and IVS8‑109A>T) allelic variants, and their clinical implications, among Mexican patients with diabetes mellitus type 2 undergoing treatment with glibenclamide and metformin 

    Cuautle-Rodríguez, Patricia; Rodríguez-Rivera, Nidia Samara; Andrés, F. de; Castillo-Nájera, Fernando; Llerena, A.; Molina Guarneros, Juan Arcadio (Spandidos Publications, 2019)
    The majority of Mexican patients with diabetes mellitus type 2 (DMT2) (67.9-85.0%) are prescribed sulpho nylureas (SUs), which are metabolized by cytochrome P450 2C9 (abbreviated as CYP2C9). SUs are a type of oral ...
  • Effects of Khat (Catha edulis) use on catalytic activities of major drug-metabolizing cytochrome P450 enzymes and implication of pharmacogenetic variations 

    Bedada, Worku; Andrés, F. de; Engidawork, Ephrem; Hussein, Jemal; Llerena, A.; Aklillu, Eleni (Springer Nature, 2018)
    In a one-way cross-over study, we investigated the efect of Khat, a natural amphetamine-like psychostimulant plant, on catalytic activities of fve major drug-metabolizing cytochrome P450 (CYP) enzymes. After a one-week ...
  • Pharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients 

    Ortega Ayala, Adiel; Rodríguez-Rivera, Nidia Samara; Andrés, F. de; Llerena, A.; Pérez-Silva, Eliseo; Espinosa-Sánchez, Adriana Guadalupe; Molina Guarneros, Juan Arcadio (MDPI, 2022-06-22)
    Mexico has been under official epidemiological alert due to diabetes since 2016. This study presents new information on the frequency and variants of metformin transporters OCT1, OCT2, OCT3, ABCB1, and CYP2C9 variants ...
  • Temporal variability measurements of PM2.5 and its associated metals and microorganims on a suburban atmosphere in the central Iberian Peninsula 

    Rodriguez, Ana; Susana, Seseña; Sanchez, Enrique; Rodríguez Pérez, María; Palop Herreros, María de los Llanos; Rodríguez Martín-Doimeadios, Rosa C.; Rodríguez Fariñas, Nuria (Elsevier, 2020-12)
    A novel and multidisciplinary observational analysis of atmospheric components in the Central Iberian Peninsula is presented here. PM2.5 concentrations and both populations of cultivable and non-cultivable microorganisms and ...
  • A sensitive resonance Rayleigh scattering sensor for dopamine in urine using upconversion nanoparticles 

    MURILLO PULGARIN, JOSE ANTONIO; Alañón Molina, Aurelia; Jiménez García, Elisa; García Gómez, Lucía (WILEY, 2019-11-14)
    A highly sensitive resonance light scattering method for detecting dopamine in urine was developed by using a novel probe based on lanthanide‐doped upconversion nanoparticles (UCNPs) linked to dopamine–quinone (DQ) ...
  • A fast and simple FIA-chemiluminescence method for the evaluationof Roselle flowers as scavenger of the free radicals generated by UVirradiated antibiotics 

    García Bermejo, Luisa Fernanda; Murillo Pulgarin, Jose Antonio; Carrasquero Durán, Armando (Elsevier, 2019-02-05)
    This work proposes a new method for the in vitro evaluation of the effect of UV irradiation on the production of free radicals and other reactive species during the photodecomposition of drugs. The method was based on the ...
  • Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd 

    Wang, Zichen; Monteiro, Caroline D.; Jagodnik, Kathleen M.; Fernández, Nicolás F.; Gundersen, Gregory W.; Rouillard, Andrew D.; Jenkins, Sherry L.; Feldmann, Axel S.; Hu, Kevin S.; McDermott, Michael G.; Duan, Qiaonan; Clark, Neil R.; Jones, Matthew R.; Kou, Yan; Goff, Troy; Woodland, Holly; Amaral, Fabio M. R.; Szeto, Gregory L.; Fuchs, Oliver; Schüssler-Fiorenza Rose, Sophia M.; Sharma, Shvetank; Schwartz, Uwe; Bengoetxea Bausela, Xabier; Szymkiewicz, Maciej; Maroulis, Vasileios; Salykin, Anton; Barra, Carolina M.; Kruth, Candice D.; Bongio, Nicholas J.; Mathur, Vaibhav; Todoric, Radmila D.; Rubin, Udi E.; Malatras, Apostolos; Fulp, Carl T.; Galindo, John A.; Motiejunaite, Ruta; Jüschke, Christoph; Dishuck, Philip C.; Lahl, Katharina; Jafari, Mohieddin; Aibar, Sara; Zaravinos, Apostolos; Steenhuizen, Linda H.; Allison, Lindsey R.; Gamallo, Pablo; Andrés, F. de; Devlin, Tyler Dae; Pérez-García, Vicente; Ma’ayan, Avi (MacMillan Publishers Limited, 2016-09-26)
    Gene expression data are accumulating exponentially in public repositories. Reanalysis and integration of themed collections from these studies may provide new insights, but requires further human curation. Here we report ...
  • LC–MS/MS simultaneous analysis of allopregnanolone, epiallopregnanolone, pregnanolone, dehydroepiandrosterone and dehydroepiandrosterone 3-sulfate in human plasma 

    Lionetto, Luana; Andrés, F. de; Capi, Matilde; Curto, Martina; Sabato, Donata; Simmaco, Maurizio; Bossù, Paola; Sacchinelli, Eleonora; Orfei, Maria Donata; Piras, Federica; Banaj, Nerisa; Spalletta, Gianfranco (Future Science Ltd., 2017-03)
    Aim: Several neuropsychopharmacological properties have been attributed to the 3#945;-reduced pregnane steroids, allopregnanolone and pregnanolone, as well as to dehydroepiandrosterone sulfate because of their ability ...
  • Can the CEIBA cocktail designed for human cytochrome P450 enzymes be used in the rat for drug interaction studies? 

    Magalhães, Paulo; Andrés, F. de; Falcão, Amílcar; Llerena, A.; Alves, Gilberto (University of Alberta, 2016)
    The CEIBA cocktail consisting of caffeine (CAF), omeprazole (OZ), dextromethorphan (DM) and losartan (LOS) was previously proposed for the clinical phenotyping of five major human cytochrome P450 (CYP) isoenzymes. This ...
  • N-Terminal Amino Acid Sequences of Intact and Cleaved Forms of Mung Bean Nuclease 

    Di Maro, Antimo; Di Giovannantonio, Luca; Delli Bovi, Pasquale; Andrés, F. de; Parente, Augusto (Thieme, 2008)
    We report, for the first time, the N-terminal amino acid sequences of both intact and cleaved forms (fragments A and B) of Mung bean nuclease, purified from sprouts of Vigna radiata or purchased from Amersham Biosciences. ...